منابع مشابه
Mutagenesis testing program.
Until recently, mutagenicity testing was done on preselected compounds in a manner in which the testing laboratories knew the identity of the substances under test and the "expected" results, i.e., positive for compounds selected because of their carcinogenicity and negative for food additives. There is no completed study in which substances were tested blind using a standardized protocol. Also...
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Alkylating agents have been studied extensively both for their biological effects and for their mode of action. There have been over the past 25 years a veritable deluge of reviews, often focusing on a single aspect or agent or adduct. It can be easily noted that certain analytical techniques were widely used. These were either neutral heating of DNA which liberates 3and 7alkyl purines and/or h...
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The aim of this short review is to summarize our recent knowledge and current ideas about the genetic control and molecular mechanisms of mutagenesis in bacteria, in order to discuss possible mechanisms of malignant transformation in mammalian cells. This review is neither a good source of relevant references nor a critical evaluation of quoted work; these can be found elsewhere (Radman, 1975, ...
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Epigenetic pathway is one of the major routes to carcinogenesis. A key enzyme involved in this pathway is DNA-MTase (DMT). There are evidences that carcinogens cause an increase in the activity of this enzyme. The increased activity is due to an increase in transcriptional control of the three forms of the enzyme, Dnm1, Dnm3a and Dnm3b [1]. The general function of DMTs was described by Berletch...
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Cancer is a genetic disease due to the accumulation of numerous mutations rendering the tumour cell insensitive to control by the local cellular environment and by the whole organism. Analysis of the frequency of appearance of human cancer as a function of age shows that between four and seven mutations in key genes are usually necessary to produce most human cancers. Interesting debates in the...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1985
ISSN: 0014-5793
DOI: 10.1016/0014-5793(85)80458-0